ZETA 1. is indicated for the spatial positioning and orientation of neurosurgical instruments used by surgeons. The device is indicated only for cranial surgery where reference to a rigid anatomical structure can be identified, does not require rigid fixation of the patient, and does not require fixation of a navigated instrument guide to the patient. The system is intended to be used in operating rooms and in less acute surgical settings such as interventional procedure suites. The use of the ZETA Cranial Navigation System for ventriculostomy, brain biopsy and transcranial magnetic stimulation require separate compatible instruments and accessories. ©️ 2026 ZETA Surgical Inc. All rights reserved. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to ZETA Surgical, its subsidiaries or affiliates. No use of any ZETA Surgical trademark, trade name, or trade dress in this site may be made without the prior written authorization of ZETA Surgical, except to identify the product or services of the company.
EVD (External Ventricular Drain) - SINGAPORE HOSPITAL
January 1, 2024
National Neuroscience Institute, Singapore
Bedside precision. Without the OR.
ZETA was deployed in a first-in-human clinical trial at Singapore’s National Neuroscience Institute to guide bedside EVD placement, without skull fixation, general anesthesia, or operating room infrastructure.
THE CHALLENGE
Emergent EVD placement is often performed freehand in ICU or ER settings, where traditional navigation systems are unavailable due to their reliance on skull fixation, general anesthesia, and OR-based infrastructure.
In these high-pressure scenarios, accuracy matters and variability can lead to complications or revision procedures, that add time, burden, cost and creates significant medical risks to patients.
OUR APPROACH
ZETA enabled frameless, real-time navigation at the bedside:
- No skull fixation
- No general anesthesia
- No heavy OR setup
- Portable, single-cart deployment
Navigation was performed directly in the ICU, bringing neurosurgical-level guidance into emergent care.
CLINICAL RESULTS
In the first-in-human study:
- 100% ideal catheter placement (vs. 32% freehand)
- 0% adverse events (vs. 28% freehand)
- 100% single-pass success (vs. 81% freehand)
- 0% revision surgeries (vs. 19% freehand)