ZETA 1. is indicated for the spatial positioning and orientation of neurosurgical instruments used by surgeons. The device is indicated only for cranial surgery where reference to a rigid anatomical structure can be identified, does not require rigid fixation of the patient, and does not require fixation of a navigated instrument guide to the patient. The system is intended to be used in operating rooms and in less acute surgical settings such as interventional procedure suites. The use of the ZETA Cranial Navigation System for ventriculostomy, brain biopsy and transcranial magnetic stimulation require separate compatible instruments and accessories. ©️ 2026 ZETA Surgical Inc. All rights reserved. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to ZETA Surgical, its subsidiaries or affiliates. No use of any ZETA Surgical trademark, trade name, or trade dress in this site may be made without the prior written authorization of ZETA Surgical, except to identify the product or services of the company.
Precision that changes outcomes
PATIENT impact
<5-minute system deployment with no skull fixation required, enabling deployment in virtually any operative setting, including emergency rooms and ambulatory centers.
100% single-pass accuracy of EVD catheter placement in a multi-center study – eliminating the need for catheter revisions and reducing the risk of ventriculostomy-related infection.
Reduces the risk of post-operative pulmonary complications and injuries associated with skull fixation in cranial procedures.
STAFFING IMPACT
No anesthesiologist or surgical tech required, thanks to a simplified workflow.
Patients can bypass Phase I PACU for procedures such as brain biopsy, reducing nursing hours and post-op care resources.
Reduces reliance on neuro-OR scrub nurses and radiology techs by taking cranial surgeries outside of the OR, easing staffing bottlenecks.
FINANCIAL IMPACT
Saves $2,150–$2,628 per EVD by avoiding costly catheter replacements and infection treatment.
Reduces $1,800 in variable OR costs per brain biopsy by minimizing procedure time.
Moving procedures such as brain biopsy cases away from neuro OR enables additional OR surgeries with up to $9,000 contribution margin per case — totaling $1.4M/year in added value for 200 annual cases.
WORKFLOW
Reduces procedure time from 5 hours to <3 hours for brain biopsies, improving case throughput.
Enables procedures outside the OR, freeing up premium surgical time for complex cases.
Submillimeter precision maintained in cranial procedures in real time even with rapid patient movement.
Feb 2026
The core of Zeta’s marker-less, real-time image guidance—built for fast setup and sub-millimetric accuracy in real clinical workflows.
REALTRACK™ Foundational Patent Published

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Oct 2025
Zeta TMS Navigation System 510(k) FDA approval
Zeta Surgical® AI-powered TMS Navigation System Receives FDA 510(k) Clearance

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Nov 2024
Zeta Surgical, Harvard Medical School, Brigham and Women's Hospital, Imperial College London
SCOUT: Skull-Corrected Optimization for Ultrasound Transducers

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Jun 2024
Zeta Surgical's AI-Powered Navigation System Successfully Completes First Clinical Study

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