ZETA 1. is indicated for the spatial positioning and orientation of neurosurgical instruments used by surgeons. The device is indicated only for cranial surgery where reference to a rigid anatomical structure can be identified, does not require rigid fixation of the patient, and does not require fixation of a navigated instrument guide to the patient. The system is intended to be used in operating rooms and in less acute surgical settings such as interventional procedure suites. The use of the ZETA Cranial Navigation System for ventriculostomy, brain biopsy and transcranial magnetic stimulation require separate compatible instruments and accessories. ©️ 2026 ZETA Surgical Inc. All rights reserved. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to ZETA Surgical, its subsidiaries or affiliates. No use of any ZETA Surgical trademark, trade name, or trade dress in this site may be made without the prior written authorization of ZETA Surgical, except to identify the product or services of the company.
PRECISION BEYOND THE OR
navigation for every case, supercharged with ai
Real–time image–guided navigation
Live, continuous surgical guidance tracking patient movement 20 times per second
Submilimeter accuracy without head fixation
ZETA ensures pinpoint precision without cranial pins or general anesthesia, enhancing safety and outcomes
Adaptable to any clinical environment
Compact, mobile, and fast to deploy — ZETA performs in operating rooms, emergency settings, and ambulatory centers
ULTRA—FAST SETUP
AI IMAGE ANALYSIS
REAL—TIME GUIDED INTERVENTION
ULTRA—FAST SETUP
AI IMAGE ANALYSIS
REAL—TIME GUIDED INTERVENTION
ULTRA—FAST SETUP
AI IMAGE ANALYSIS
REAL—TIME GUIDED INTERVENTION
Our platform creates game–changing impact for a wide range of minimally–invasive and non–invasive procedures.
USE CASES
External Ventricular Drain
In our breakthrough clinical study, ZETA helped surgeons achieve exceptional accuracy in bedside external ventricular drain cases.
100% single-pass catheter placement (vs 81% freehand). 0% revision surgeries (vs 19% freehand). 0% adverse events (vs 28% freehand). 100% ideal placement (vs 32% freehand).
Brain Biopsy
By eliminating the need for skull fixation and anesthesia, ZETA makes bedside brain biopsy a possibility, freeing up OR resources and improving surgery efficiency.
>2h estimated saving in procedure time.
Transcranial Magnetic Stimulation
ZETA brings neurosurgical level accuracy to TMS therapy, enabling clinicians to repeatedly target a precise point across sessions and improve treatment efficiency.
<1mm positional accuracy.
<1° angular accuracy.
Tumor Resection
ZETA allows for tumor resections such as cavernoma resections to be performed without cranial skull fixation, in settings such as ambulatory surgical centers.
<1h estimated time to perform a cavernoma resection
We improve REAL-TIME NAVIGATION FOR PATIENTS HOSPITALS AND CLINICIANS.
BACKED BY LEADING HEALTHCARE PROFESSIONALS
Dr. Wiliiam Gormley
Dr. Ress Cosgrove
DR. MATTHEW MCGIRT
Dr. Kyle Wu
DR. JOSHUA BROWN
Dr. Faith Roberson
DR. ELAD LEVY
Dr. Chengyuan Wu
Dr. Brian Nahed
Dr. Aimee Degaetano
Alvaro Pascual-Leone
Dr. Wiliiam Gormley
Dr. Ress Cosgrove
DR. MATTHEW MCGIRT
Dr. Kyle Wu
DR. JOSHUA BROWN
Dr. Faith Roberson
DR. ELAD LEVY
Dr. Chengyuan Wu
Dr. Brian Nahed
Dr. Aimee Degaetano
Alvaro Pascual-Leone
Dr. Chengyuan Wu
DR. MATTHEW MCGIRT
Dr. Wiliiam Gormley
DR. JOSHUA BROWN
Dr. Ress Cosgrove
Dr. Aimee Degaetano
DR. ELAD LEVY
Dr. Faith Roberson
Dr. Kyle Wu
Dr. Brian Nahed
Alvaro Pascual-Leone
Dr. Chengyuan Wu
DR. MATTHEW MCGIRT
Dr. Wiliiam Gormley
DR. JOSHUA BROWN
Dr. Ress Cosgrove
Dr. Aimee Degaetano
DR. ELAD LEVY
Dr. Faith Roberson
Dr. Kyle Wu
Dr. Brian Nahed
Alvaro Pascual-Leone
Research partners
May 2026
The system will be utilized at HOPE Therapeutics in West Palm Beach, Florida, to deliver high-precision navigated Transcranial Magnetic Stimulation (TMS) for the treatment of Major Depressive Disorder and other neurological conditions.
ZETA SURGICAL Announces First Commercial Deployment of Zeta TMS Navigation System at HOPE Therapeutics
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May 2026
Zeta Navigation System, alongside its navigated instruments, Zeta Stylet and Zeta Bolt, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA).
Zeta Surgical® Receives FDA 510(k) Clearance Expanding Access to Brain Tumor Biopsies, Hydrocephalus, and Trigeminal Neuralgia
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Apr 2026
The prototype is being developed in partnership with Zeta Surgical, Inc., whose AI-powered neuronavigation platform received FDA 510(k) clearance for TMS navigation in October 2025.
NRx Pharmaceuticals Advances Robotic-Enabled Transcranial Magnetic Stimulation Combined with Neuroplastic Therapy for Military and First Responder Applications
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Feb 2026
The core of Zeta’s marker-less, real-time image guidance—built for fast setup and sub-millimetric accuracy in real clinical workflows.
REALTRACK™ Foundational Patent Published
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Design awards
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