ZETA 1. is indicated for the spatial positioning and orientation of neurosurgical instruments used by surgeons. The device is indicated only for cranial surgery where reference to a rigid anatomical structure can be identified, does not require rigid fixation of the patient, and does not require fixation of a navigated instrument guide to the patient. The system is intended to be used in operating rooms and in less acute surgical settings such as interventional procedure suites. The use of the ZETA Cranial Navigation System for ventriculostomy, brain biopsy and transcranial magnetic stimulation require separate compatible instruments and accessories. ©️ 2026 ZETA Surgical Inc. All rights reserved. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to ZETA Surgical, its subsidiaries or affiliates. No use of any ZETA Surgical trademark, trade name, or trade dress in this site may be made without the prior written authorization of ZETA Surgical, except to identify the product or services of the company.
Precision that STRENGTHENS EVERY TREATMENT SESSION
PATIENT impact
ZETA delivers sub-millimeter targeting accuracy (0.45 mm mean translational error), compared with 2–5 mm reported in many existing TMS navigation systems.
By maintaining on-target coil positioning, navigation preserves cortical dose fidelity—avoiding reductions that can fall to less than half of the intended electric field with misalignment.
As accelerated protocols such as SNT demonstrate remission rates of 57% in randomized trials and up to 90% in open-label studies, precise and consistent targeting becomes essential to fully realize their therapeutic potential.
STAFFING IMPACT
Real-time AI-powered tracking automates patient registration and motion compensation, reducing operator-dependent variability.
The system is designed for technician-led operation, minimizing reliance on specialist time while maintaining anatomical precision.
With setup in approximately one minute, daily workflows become more predictable and treatment capacity increases across providers.
FINANCIAL IMPACT
Under ZETA’s AI-enabled workflow, a single TMS suite can support up to five full treatment courses per week—maximizing clinical capacity within a standard outpatient room.
A technician-led operating model reduces specialist time requirements while supporting scalable, economically efficient outpatient delivery.
With setup times of approximately one minute—compared to more than ten minutes in many existing systems—navigation increases daily treatment throughput per suite.
WORKFLOW
Deployment in minutes and single-cart portability enable seamless integration into outpatient clinics without dedicated navigation infrastructure.
RealTrack™ AI technology provides automatic, real-time patient registration and tracking, maintaining precision even during patient movement.
Feb 2026
The core of Zeta’s marker-less, real-time image guidance—built for fast setup and sub-millimetric accuracy in real clinical workflows.
REALTRACK™ Foundational Patent Published

NEWS
PUBLICATION

NEWS
PUBLICATION
Oct 2025
Zeta TMS Navigation System 510(k) FDA approval
Zeta Surgical® AI-powered TMS Navigation System Receives FDA 510(k) Clearance

NEWS
PUBLICATION

NEWS
PUBLICATION
Nov 2024
Zeta Surgical, Harvard Medical School, Brigham and Women's Hospital, Imperial College London
SCOUT: Skull-Corrected Optimization for Ultrasound Transducers

NEWS
PUBLICATION

NEWS
PUBLICATION
Jun 2024
Zeta Surgical's AI-Powered Navigation System Successfully Completes First Clinical Study

NEWS
PUBLICATION

NEWS
PUBLICATION